PVP is inert and does not participate in everyone's metabolism. Both NVP and PVP are soluble in water and can be polymerized by azo initiators to generate linear PVP polymer compounds. Moreover, AIBN contains cyano groups that are harmful to humans, while most water-soluble azo initiators It does not contain cyano groups, and PVP is mostly used in direct contact with the human body, so the water-soluble azo initiator has more advantages than AIBN. Add 0.4 g dispersing agent PNVP-co-VAc and 80 g dispersing medium ethyl acetate into a 250 mL four-neck flask, stir to dissolve in a 70℃ constant temperature water bath, add 20 g monomer NVP and 0.15 g initiator AIBN, under nitrogen atmosphere After reacting for 6 hours, cooling and filtering, the insoluble matter was placed in a vacuum drying box and dried under vacuum for 24 hours to obtain a white PVP solid powder.

Most of the PVP polymerization uses AIBN as the initiator. There is no literature on the use of water-soluble azo initiators to initiate the synthesis of PVP, but some people are doing work in this area. As a synthetic water-soluble polymer compound, PVP has the general properties of water-soluble polymer compounds, such as colloidal protection, film-forming properties, adhesiveness, hygroscopicity, solubilization or cohesion. What is important is its excellent solubility and physiological compatibility. In synthetic polymers, PVP is soluble in water and most solvents, with low toxicity and good physiological compatibility. It is rare, especially in the fields of medicine, food, cosmetics, which are closely related to people’s health. In, with the price of its raw material butyrolactone, it will definitely show its good prospects for development.

It also has excellent biocompatibility and does not cause irritation to skin, mucous membranes, eyes, etc. Pharmaceutical grade PVP is one of the three new excipients advocated. It can be used as a binder for tablets and granules, a cosolvent for injections, and a glidant for capsules; detoxifiers, prolonged effects, lubricants and packages for eye drops. Coating film-forming agent, dispersant for liquid preparation, enzyme and heat-sensitive stabilizer, can also be used as cryopreservation agent. Used in contact lenses to increase their hydrophilicity and lubricity. PVP K30 has been officially listed on the market with the approval of the pharmaceutical management department.